PRELIMINARY STUDY FOR PREPARATION OF COMBINED ATTENUATED VACCINE AGAINST SHEEP POX AND PPR VIRUSES.
- Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo,Egypt,Rinder pest like disease department.
- Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo,Egypt, Sheep pox department.
- Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo, Egypt, Render pest department.
- Central Laboratories for Evaluation of Veterinary Biologics, Abbasia, Cairo,Egypt.
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Abstract
The present study was performed to evaluatethe safety and immunogenicity of combined sheep pox (SP) and Peste des Petits ruminants (PPR) vaccine prepared in a lyophilized form. A sheepgroup was vaccinated with the field dose of the prepared combined vaccine subcutaneouslyand the cellular and humeral immune responses of vaccinated sheep were evaluated for six months by different serological tests and compared with the response of eachvaccine alone as a control. It was found that the vaccinated sheep became protected from the 2nd week post vaccination and keep the protective level till the end of the experiment (24 week). The combined vaccine was found to be safe and potent as evident from sero conversion as well as challenge studies in sheep. We concluded that the use of the prepared combined vaccine component did not interfere with each otherand can be used for economic vaccination strategies.
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How to Cite This Article
Zeidan S.M, Namaa A. Mohamed, Hanan M.S.ELZawahry, Saad M.A.A, Olfat E. Nakhla, Afaf A.Abdel-wahab, Abeer A. Tammam and El-Dakhly A.T (2016); PRELIMINARY STUDY FOR PREPARATION OF COMBINED ATTENUATED VACCINE AGAINST SHEEP POX AND PPR VIRUSES., Int. J. of Adv. Res., 4 (04), 212-219, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/126
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