THE SENSETIVITY OF LIVER, KIDNEY AND OVARIES OF PREGNANT RATS TO OXIDATIVE STRESS INDUCED BY BISPHENOL- A.

Bisphenol-A (BPA) is a worldwide used endocrine disruptor that is incorporated in many plastic industries. The exposure of humans to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of such substances. The aim of the present study is to evaluate the extent to which BPA can affect the liver, kidney and ovaries by measuring the oxidative stress induced by two different doses of BPA in these organs of pregnant rats; these rats were treated to different oral doses of BPA (25 mg/kg, 50mg/kg and 50mg/kg/b.wt). The oxidative stress arising from BPA was evaluated in liver, kidney and ovary tissues. In addition, serum urea and createnine levels as markers of kidney function together with the activities of MDA, catalase, GSH, GST as markers of liver function were measured. The results of the present study showed significant changes in the antioxidant mechanisms in the liver, kidney and morphological changes in ovaries with the lower (25 mg/kg, 50mg/kg for 9-days) and higher doses of BPA (500 mg/kg for 9-days). It could be concluded that BPA-induced toxicity is mediated by oxidative stress which was prominent in liver, kidney and ovaries after the exposure to both the higher and lower doses.