UV – SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF ACAMPROSATE CALCIUM IN BULK AND TABLET DOSAGE FORM

A simple, rapid, accurate, precise, and economical spectrophotometric method for estimation of Acamprosate calcium in tablet dosage form has been developed. Beer-Lambert’s law was followed in the concentration range of 10-50?g/ml (r2= 0.989). LOD and LOQ were found to be 0.183 ?g/ml & 0.55 ?g/ml respectively. The result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The method was validated by determining its accuracy and precision which proved suitability of the developed method for the routine estimation of Acamprosate calcium in solid dosage form.