EPIGENETIC MODIFICATION OF GENES INVOLVED IN LATENCY OF VIRUSES CAUSING ORAL DISEASES.

Viruses encompassing the members of the herpes simplex viruses (HSV), human immunodeficiency viruses (HIV), respiratory viruses inclusive of adeno, respiratory syncytial viruses and influenza viruses, oncogenic viruses like polyoma and papilloma are presently the subject of intense interest with respect to epigenetics playing its role in implementing various oral health issues. In near decades, primary focus may be oriented towards the role of histone modification, nucleosome location and DNA methylation in regulating the biological consequences of oral viral infections. These epigenetic mechanisms underlying oral viral illnesses are understood by a wide variety of strategies and techniques used to identify the histone modifications and DNA methylation site. Aim of this review is to highlight the epigenetic mechanisms behind oral viral diseases which may play an inherent role in the regulation of the viral genes and their transformation in the oro-mucosal layers.