EXPRESSION OF CagA GENE IN HELICOBACTER PYLORI ISOLATED FROM DENTAL PLAQUE OF MALE SNUFF USERS.
- Lecturer, Department of Physiology, National Medical College and Teaching Hospital, Birjunj, Nepal.
- Lecturer, Department of Biochemistry, National Medical College and Teaching Hospital, Birjunj, Nepal.
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Helicobacter pylori is recognized as the major etiological agent of chronic gastritis,gastric adenocarcinoma and lymphoma. Stomach lining along withSaliva have some carcinogenic Helicobacter pylori.The present study was carried out to investigate the presence of Helicobacter pylori in dental plaque sample collected from snuff addicted male person (who have been using snuff for >20 years)from Raxaul, Bihar and to study the probable relation between snuff and expression of CagA gene. Here, sixty three bacterial isolates from study group were identified as Helicobacter pylori. Out of them forty two wereCagA positive. Only twenty one bacterial isolates from control group were identified as Helicobacter pylori and two of them possess CagA gene.Result of this study conclude that snuff may stimulate the expression of CagA gene and may one of the potential threat for the development of oral cancer.
[Debnarayan Jana and Anup Shamsher Budhathoki. (2016); EXPRESSION OF CagA GENE IN HELICOBACTER PYLORI ISOLATED FROM DENTAL PLAQUE OF MALE SNUFF USERS. Int. J. of Adv. Res. 4 (May). 734-738] (ISSN 2320-5407). www.journalijar.com
