10Sep 2017


  • Department of pharmaceutics, college of pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, 641044. Tamil nadu, India.
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Cancer is still one of the most dangerous diseases worldwide. The application of nanotechnology in medicine, known as nano medicine, has paved a way for introduction of nanoparticles in treating serious disease such as cancer. Nanotechnology differentiates cancer cells from normal cells by active and passive targeting which is essential in cancer treatment. Metal nanoparticle find application in cancer diagnosis, treatment and monitoring all in a single product enhance patient compliance and minimising potential adverse effects. Gold and silver are known as noble metals and the nanoparticles fabricated from these noble metals find number of applications in cancer imaging, photodiode therapy, hyperthermia and tissue targeting and they enable clinicians in early diagnosis and treatment of various cancer. The safety issues mainly toxicity on long time usages of this noble metal nanoparticles are to be addressed. This review highlights the unique properties, clinical applications of noble metal nanoparticles and its challenges.

  1. Reza Fekrazad,Nafiseh Naghdi, Hanieh Nokhbatolfoghahaei, Hossein Bagheri,The Combination of Laser Therapy and Metal Nanoparticles in Cancer Treatment OriginatedFrom Epithelial Tissues: A Literature Review,J Lasers Med Sci 2016 Spring;7(2):62-75.
  2. Barnard RJ. Prevention of cancer through lifestyle changes.?Evid.Based Complementary Altern. Med.?2004;1:233?239.
  3. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.?Int. J. Cancer.?2010;127:2893?2917.
  4. Choi , Young-Eun,Ju-won kwak,andJoon W Park?Nanotechnology for early cancer detection.: Sensors 10.1(2010);428-55.
  5. Maeda H. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond.?J. Control. Release.?2012; 164:138?144.
  6. Byrne JD, Betancourt T, Brannon-Peppas L. Active targeting schemes for nanoparticle systems in cancer therapeutics.?Adv. Drug Deliv. Rev.?2008; 60:1615?1626.
  7. Tapan K. Sau (International Institute of Information Technology, Hyderabad, India) and Andrey L. Rogach (City University of Hong Kong, Hong Kong), Wiley-VCH Verlag& Co KGaA, Weinheim, Germany, 2012, 582.
  8. Retif, P,S. Pinel,M. Barberi-Heyob. 2015. Nanopartticles for radiation therapy -enhancement: the key parameters.. Theranos-tics.5:1030-1044.
  9. Denisa Ficai, Anton Ficai and Ecaterina Andronescu ,2015.Advances in Cancer Treatment: Role of Nanoparticles,Nanomaterials-Toxicity and Risk assessment ,1-5.
  10. Bu, S. Lee, ?Influence of dopamine concentration and surface coverage of Au shell on the optical properties of Au, Ag, and AgcoreAushell nanoparticles?, ACS Appl. Mater. Interfaces vol.4, pp. 3923-3931, 2012.
  11. Carlson C., Hussain S.M., Schrand A.M., Braydich-Stolle L.K., Hess K.L., Jones R.L., Schlager J.J. Unique cellular interaction of silver nanoparticles: Size-dependent generation of reactive oxygen species. J. Phys. Chem. B. 2008;112:13608?13619. doi: 10.1021/jp712087m.
  12. D. Evanoff Jr. and G. Chumanov, ?Synthesis and optical properties of silver nanoparticles and arrays,? ChemPhysChem, vol. 6, no. 7, pp. 1221?1231, 2005.
  13. R. Panyala, E. M. Pena?-Mendez,? and J. Havel, ?Silver or silver nanoparticles: a hazardous threat to the environment and human health?? Journal of Applied Biomedicine, vol. 6, no. 3, pp. 117?129, 2008.
  14. Gopinath P., Gogoi S.K., Chattopadhyay A., Ghosh S.S. Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy. Nanotechnology. 2008;19:075104. doi: 10.1088/0957-4484/19/7/075104.
  15. Wang H.J., Yang L., Yang H.Y., Wang K., Yao W.G., Jiang K., Huang X.L., Zheng Z. `Antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes. J. Inorg. Biochem. 2010;104:87?91. doi: 10.1016/j.jinorgbio.2009.10.015.
  16. Sanpui P., Chattopadhyay A., Ghosh S.S. Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier. ACS Appl. Mater. Interfaces. 2011;3:218?228. doi: 10.1021/am100840c.
  17. Locatelli E., Naddaka M., Uboldi C., Loudos G., Fragogeorgi E., Molinari V., Pucci A., Tsotakos T., Psimadas D., Ponti J., et al. Targeted delivery of silver nanoparticles and alisertib: In vitro and in vivo synergistic effect against glioblastoma. Nanomedicine. 2014;9:839?849. doi: 10.2217/nnm.14.1.
  18. Krishnaraj, P. Muthukumaran, R. Ramachandran, M. Balakumaran, and P. Kalai chelvan, ?Acalypha indica Linn: biogenic synthesis of silver and gold nanoparticles and their cytotoxic effects against MDA-MB-231, human breast cancer cells,? Biotechnology Reports, vol. 4, pp. 42?49, 2014.
  19. Rajasekharreddy and P. U. Rani, ?Biofabrication of Ag nanoparticles using Sterculia foetida L. seed extract and their toxic potential againstmosquito vectors and HeLa cancer cells,?Materials Science and Engineering C, vol. 39, no. 1, pp. 203?212,2014.
  20. Sankar, A. Karthik, A. Prabu, S. Karthik, K. S. Shivashangari, and V. Ravikumar, ?Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity,?Colloids and Surfaces B: Biointerfaces, vol. 108, pp. 80?84, 2013.
  21. J. Firdhouse and P. Lalitha, ?Biosynthesis of silver nanoparticles using the extract of Alternanthera sessilis?antiproliferative effect against prostate cancer cells,? Cancer Nanotechnology, vol.4, no. 6, pp. 137?143, 2013.
  22. Govender, A. Phulukdaree, R. M. Gengan, K. Anand, and A.A. Chuturgoon, ?Silver nanoparticles of Albizia adianthifolia: the induction of apoptosis in human lung carcinoma cell line,?Journal of Nanobiotechnology, vol. 11, no. 1, article 5, 2013.
  23. Sriram MI, Kanth SB, Kalishwaralal K, Gurunathan S. Antitumor activity of silver nanoparticles in Dalton?s lymphoma ascites tumor model. Int J Nanomed. 2010;5(1):753?762.
  24. Gurunathan S, Lee KJ, Kalishwaralal K, Sheikpranbabu S, Vaidyanathan R, Eom SH. Antiangiogenic properties of silver nanoparticles. Biomaterials. 2009;30(31):6341?6350.
  25. Xi-Feng Zhang,1 Zhi-Guo Liu,1 Wei Shen,2 and Sangiliyandi Gurunathan3,Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches, Int J Mol Sci. 2016 Sep; 17(9): 1534, Published online 2016 Sep 13. doi: 3390/ijms17091534.
  26. Wicki A., Witzigmann D., Balasubramanian V., Huwyler J. Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications. J. Control. Release. 2015;200:138?157. doi: 10.1016/j.jconrel.2014.12.030.
  27. Link S, El-Sayed MA. Optical properties and ultrafast dynamics of metallic nanocrystals. Annu Rev Phys Chem. 2003;54:331?66.
  28. J. Wang Yz Hb and X. J. Liang, ?Current status of nanotechnology applied in biomedicine,? Acta Biophysica Sinica, vol. 25, no. 3, pp. 168?174, 2009.
  29. Raji V, Kumar J, Rejiya CS, Vibin M, Shenoi VN, Abraham A. Selective photothermal efficiency of citrate capped gold nanoparticles for destruction of cancer cells. Exp Cell Res. 2011;317(14):2052?2058. doi: 10.1016/j.yexcr.2011.04.010.
  30. Turkevich J, Stevenson PC, Hillier J. A study of the nucleation and growth processes in the synthesis of colloidal gold. Discuss Faraday Soc. 1951;11:55?75.
  31. Frens G. Controlled nulceation for regulation of particle size in monodisperse gold suspensions. Na Phys Sci. 1973;241:20?2.
  32. Subrata K, Sudipa P, Snigdhamayee P, Soumen B, Sujit KG, Anjali P, et al. Anisotropic growth of gold clusters to gold nanocubes under UV irradiation. Nanotechnology. 2007;18:075712.
  33. Kang B, Mackey MA, El-Sayed MA. Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis. J Am Chem Soc. 2010;132:1517?9.
  34. S. Day, L. Zhang, P.A. Thompson, J.A. Zawaski, C.C. Kaffes, M.W. Gaber, S.M. Blaney, J.L. West Vascular-targeted photothermal therapy of an orthotopic murine glioma model Nanomedicine, 7 (2012), pp. 1133?1148.
  35. Busbee BD, Obare SO, Murphy CJ. An improved synthesis of high-aspect-ratio gold nanorods. Adv Mater. 2003;15:414?6.
  36. Kim J, Park S, Lee JE, Jin SM, Lee JH, Lee IS, et al. Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy. Angew Chem Int Ed Engl. 2006;45:7754?8.
  37. Chen J, Saeki F, Wiley BJ, Cang H, Cobb MJ, Li ZY, et al. Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. Nano Letters. 2005;5:473?7.
  38. Marija Matulionyte, Dominyka Dapkute, Laima Budenaite , Greta Jarockyte 1 and Ricardas Rotomskis , Photoluminescent Gold Nanoclusters in Cancer Cells: Cellular Uptake, Toxicity, and Generation of Reactive Oxygen Species, Int. J. Mol. Sci. 2017, 18, 378; doi:10.3390/ijms18020378.
  39. Harmsen S, Huang R, Wall MA, Karabeber H, Samii JM, Spaliviero M, White JR, Monette S, O\'Connor R, Pitter KL, Sastra SA, Saborowski M, Holland EC, Singer S, Olive KP, Lowe SW, Blasberg RG, Kircher MF,Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging, Sci Transl Med. 2015 Jan 21;7(271):271ra7. doi: 10.1126/scitranslmed.3010633.
  40. Xiao-Long Zhang Cheng ZhengYun ZhangHuang-Hao YangXiaolong LiuEmail authorJingfeng Liu, One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy, Journal of Nanoparticle Research,July 2016, 18:174.
  41. Jo?o Conde,1,2 Gon?alo Doria,1 and Pedro Baptista1Noble Metal Nanoparticles Applications in Cancer, Journal of Drug Delivery, Volume 2012 (2012), Article ID 751075, 12,doi.org/10.1155/2012/751075.
  42. Konstantin Sokolov, Jasmine Tam, Justina Tam, Kort Travis, Tim Larson, Jesse Aaron, Nathan Harrison, Stanislav Emelianov, and Keith Johnston, Cancer Imaging and Therapy with Metal Nanoparticles, 31st Annual International Conference of the IEEE EMBS Minneapolis, Minnesota, USA, September 2-6, 2009.

[M. raja, amutha gnana arasi, m. gopal rao and b. anandhi. (2017); NOBLE METAL NANOPARTICLES IN CANCER THERAPY: PROPERTIES CHALLENGES AND CLINICAL APPLICATIONS. Int. J. of Adv. Res. 5 (9). 127-135] (ISSN 2320-5407). www.journalijar.com

Department of pharmaceutics, college of pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, 641044. Tamil nadu, India.


Article DOI: 10.21474/IJAR01/5310       DOI URL: http://dx.doi.org/10.21474/IJAR01/5310

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