COMPARATIVE IN VITRO STUDIES OF ANTIMICROBIAL ACTIVITIES OF RAW AND RIPEN PULP OF CARICA PAPAYA AGAINST SOME HUMAN PATHOGENS.

Present study evaluates the antibacterial activity of Carica papayafruit (unripe and ripe) extracts obtained in different solvents (Petroleum ether, Chloroform and Ethyl acetate). The extracts werestudied against various diseases causing pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella enterica and Micrococcus luteus using agar well diffusion method. The ethyl acetate extract of raw papaya pulp was found more active against S. enterica with zone of inhibition 20 mm. Extract of petroleum ether and chloroform also showed activity against P. aeruginosa and S. enterica with inhibition zone 15 mm and 17 mm respectively. Extracts of ripenpulp showed no or less activity against any of these tested pathogens. Chloroform showed moderate activity with the inhibition zone 15 mm against S. enterica followed by P. aeruginosa with inhibition zone 14 mm. when these results were compared to the results of standard drugs,raw papaya pulp found more effective against pathogens than the other. Minimum inhibitory concentration was calculated and maximum values lies between 10- 20 mg/ml.This research concludes that rawpapaya has potential natural antibacterial compoundswhichcan aid in further investigation.