PREVALANCE, ENDOSCOPIC AND HISTOPATHOLOGICAL FEATURES OF HELICOBACTER PYLORI (H.PYLORI) INFECTION IN CHRONIC KIDNEY DISEASE (CKD) / END STAGE RENAL DISEASE (ESRD) VERSUS NORMAL POPULATION AT A TERTIARY CARE CENTER IN NORTH INDIA: A CASE CONTROL HOSPITAL BASED STUDY.

Objectives: To determine the prevalence of H.Pylori infection, esophagogastrodudenoscopy (EGD) and pathological findings among patients of chronic kidney disease (CKD) versus normal population. METHODS: This study was carried out from October 2012 to November 2014.Seventy (70) patients of CKD (Cases) underwent upper GI endoscopy (EGD). Endoscopic changes were described and antral gastric biopsies were taken one for Histopathological examination and another for detection of H.Pylori by Rapid urease test (RUT). These findings were compared to findings in 50 consecutive patients (controls) with normal renal function undergoing endoscopy (EGD) for assessment of dyspepsia. RESULTS: The Endoscopic findings were abnormal in 63 (90%) among cases with antral gastritis as most common finding in 29 (42%) and among controls.EGD findings were abnormal in 39 (78%) patients with antral gastritis in 16(32%)( p-value=0.436).Among 70 cases; RUT was positive in 57(81.4%), Negative in 10(14.3%) and among 50 Controls; RUT was positive in 42 (84%),Negative in 8 (16%) patients (p-value=0.445).On HPE for H.Pylori detection among cases H.Pylori was positive in 52(74.3%),Negative in 15 (21.4%) and among controls H.Pylori was positive in 40(80%),Negative in 9(18%) (P-value=0.698).The HPE findings on microscopy among cases reveals chronic active gastritis as most common finding seen in 51(72.9%) and among controls chronic active gastritis was seen in 34(68%)(p value=0.166). Conclusion: The prevalence of H.Pylori infection, Endoscopic and pathological findings are same among patients of CKD and Normal population with GI Symptoms with antral gastritis as most common finding on endoscopy. Chronic active gastritis as most common Histopathological diagnosis.