Vol. 5 (12) pp. 156-160 DOI: 10.21474/IJAR01/5950

TOXIC EFFECTS ON BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS IN RATS EXPOSED TO JUDO 40.

and
  • Department of Department of Natural Resources, Sabaragamuwa University, Belihuloya, Sri Lanka.
  • Department of Zoology (Center for Biotechnology), University of Sri Jayewardenepura.
10 Downloads 104 Views
Crossref

Download Full Paper (PDF)

Abstract

The present study investigated the hematological, and biochemical, changes due to Judo 40 toxicity in male Wistar albino rats. Two sets of male rats (n=9/group) were orally treated with 20 mg/kg and 50 mg/kg of Judo 40 or the vehicle (corn oil) in four fractions for two consecutive days. The first of animals were autopsied on day 1 to assess the liver toxicity while the second set of animals were autopsied on post-treatment day 3 to assess hematological parameters. Both doses of Judo 40 intoxication induced a significant increase in PCV, and WBCs count. Moreover, there was a significant increase in serum biochemical parameters related to hepatic injury: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP). In general, it was concluded that, Judo 40 could induce hepatotoxicity and alter PCV and WBC counts indicating exposure to Judo 40 could pose risk to human health.

Keywords

Article Analytics

References

  1. Bacchetta C., Cazenave J., Parma M.J. & Biancucci, G.F. (2011). Biochemical stress responses in tissues of the cichlid fish Cichlasoma dimerus exposed to a com- mercial formulation of endosulfan. Archives of Envrionmental Contamination 61: 453?460,
  2. Bhattacharya H., Xiao Q. & Lun L. (2008). Toxicity studies of nonylphenol on rosy barb (Puntius conchonious): a biochemical and histopathological evaluation. Tissue Cell 40: 243?249.
  3. Brandt, C., Burnett, D.C., Arcinas, L., Palace, V., Anderson, W., G. (2015). Effects of chlorpyrifos on in vitro sex steroid production and thyroid follicular development in adult and larval lake Sturgeon Acipenser fulvescens. Chmosphere, 132:179-197
  4. Colovic M.B., Krstic, D. Z., Lazarevic-Past, T.D., Bondzic, A.M., Vasic, V.M. (2013). Acetylcholine esterase inhibitors: Pharmacology and Toxicology. Current Neruopharmacol, 11 (3): 315-335.
  5. David M., Mushigeri S.B., Shivakumar R. & Philip G.H. (2004). Response of Cyprinus carpio (Linn) to sublethal concentration of cypermethrin: alterations in protein metabolic profiles. Chemosphere 56 (4): 347?352.
  6. Dayananda P.V. & Peiris L Dinithi C (2016 a). Morphological and functional alterations of human spermatozoa after incubation with two organophosphorus insecticides. Wulfenia Journal. 23(10):1-9.
  7. Dyananda P.V. & Peiris L. Dinithi C (2016 b). Toxic effects of Tebufenozide on human sperm in vitro. International Journal of Advanced Scientific Research. 5(6): 61-72.
  8. Deb N. & Das S. (2013) Chlorpyrifos toxicity in fish: A review. Current World Environment Journal 8: 174-184.
  9. Dhanushka M.A.T. & Peiris L.D.C. (2017). Cytotoxic and Genotoxic Effects of Acephate on Human Sperm. Journal of Toxicology, vol. 2017, Article ID 3874817, 6 pages, 2017. doi:10.1155/2017/3874817.
  10. Di Giulio R.T. & Hinton, D.E. (2008). The Toxicology of Fishes. CRC Press, New York.
  11. Giannini E.G., Testa R. & Savarino V. (2005). Liver enzyme alteration: a guide for clinicians. Canadian Medical Association Journal 172(3):367-37
  12. Mairb?url H. (2013). Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells. Frontiers in Physiology. 4: 332.
  13. Mauro P., Renze B. & Wouter W. (2006). In: Tietz text book of clinical chemistry and molecular diagnostics. 4th edition. Carl AB, Edward R, David EB, editors. Elsevier pp. 604?616.
  14. Mellgren E. (2011). Glycerol to diary calves ? effects on intestinal health and fluid balance. M.Sc. Thesis, Swedish University of Agricultural Science, Uppsala, Sweden.
  15. Peiris D.C. & Dhanushka T (2017). Low doses of chlorpyrifos interfere with spermatogenesis of rats through reduction of sex hormones. Environmental Science and Pollution Research. 24(26):20859-20867.
  16. Peiris D.C., Jayatilleka H. & Dhanushka T (2015). Evaluation of aqueous leaf extract of Cardiospermum halicacabum (L.) on fertility of male rats. Biomed Central International Research 2015; Article ID: 175726,
  17. Peiris L.D.C., Jayathunga YNA, Ratnasooriya W.D. (1995). Antirepro-ductive effects in male rats exposed to methamidophos. Ceylong Journal of Science; 24: 53-9.
  18. Peiris L.D.C. & Moore H.D.M. (2001a). Effects of acute and chronic doses of methoxy acetic acid on hamster sperm fertilizing ability. Asian Journal of Andrology 3: 209-216.
  19. Peiris L.D.C. & Moore H.D.M. (2001b). Effects of acute and chronic doses of methoxy acetic acid on hamster sperm fertilizing ability
  20. Peiris-John R.J. & Wickremasinghe R. (2008) Impact of low-level exposure to organophosphates on human reproduction and survival. Transaction of the Royal Society of Tropical Medicine and Hygiene 102: 239?245.
  21. Ratnasooriya W.D., Jayatunga Y.N.A. & Peiris L.D.C. (1996). Monocrotophos impairs the fertility of male rats. Medical Science Research 24: 403 406.
  22. Skakkebaek N E. J?rgensen N. Main K M. Rajpert-De Meyts E. Leffers H. & Andersson A M. et al (2006). Is human fecundity declining? International Journal of Andrology 29: 2?11.
  23. van der Oost R., Beyer J. & Vermeulen, N.P.E. (2003). Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environ. Toxicology & Pharmacology 13: 57?149.

How to Cite This Article

Inoka Kudavidanage and L. Dinithi C. Peiris. (2017); TOXIC EFFECTS ON BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS IN RATS EXPOSED TO JUDO 40., Int. J. of Adv. Res., 5 (12), 156-160, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/5950

Corresponding Author

L Dinithi C Peiris
Department of Zoology, University of Sri Jayewardenepura, Gangodawila, Nugegoda, 10250, Sri Lanka.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.