COMPARATIVE STUDY OF HAEMODYNAMIC CHANGES AND BLOOD SUGAR LEVELS BEFORE AND AFTER INDUCTION OF GENERAL ANAESTHESIA WITH ETOMIDATE AND PROPOFOL.

Background: an ideal inducing agent for general anaesthesia should have hemodynamic stability, minimal respiratory side effects and rapid clearance. Presently intravenous drugs such as propofol and etomidate are the most safe for induction of general anaesthesia. [2-4] Methodology: in the ot patient received iv midazolam 0.03 mg/kg and iv fentanyl 2mcg/kg five minutes before induction, and was preoxygenated with 100% oxygen. Patient was induced with iv propofol at the dose of 2.5 mg/kg body weight as a induction agent @<15 sec, and iv etomidate 0.3 mg/kg body weight, for group p and group e respectively iv using peripheral cannula, until the patient?s verbal response was lost. Then iv succinylcholine 1.5mg/kg was used as muscle relaxant in both the groups and intubation was done after ippv, connected to work station and continued with nitrous oxide and oxygen mixture (70:30) and inhalational agent was used to maintain the anaesthesia. After 5 mins of induction, patients blood sugar was recorded in both the groups. Later on as soon as intermediate muscle relaxant was administered i.e. Injection atracurium 0.5mg/kg and continued. Results and conclusions: from our results and comparison with other studies we conclude that; 1. Etomidate is hemodynamically more stable as induction agent than propofol. 2. Both etomidate and propofol affect blood sugar levels after induction but this affect is slightly more marked in etomidate group as compared to propofol group.