ANTI-INFLAMMATORY AND ANTISEPTIC ACTIVITY OF ANCIENT TRADITIONAL SIDDHA DRUG THIPPILI RASAYANAM IN PEDIATRIC CARE.

Background: Inflammation of the tonsils usually occurs secondary to viral or bacterial origin.The objective of this study was to assess the anti inflammatory and antiseptic potential of traditional drug ThippiliRasayanam against tonsillitis in pediatirc care. Materials and Methods:Wistar rats of either sex weighing 180-220g are procured from Central Animal House, J.S.S. College of Pharmacy, Ootacamund,India. Experimental protocol was approved from Institutional Animal Ethical Committee and carried out as per CPCSEA guidelinesThe anti inflammatory of the drug was evaluated using carrageenan- induced paw oedema method. .The anti septicactivity was studied in excision wound healing model in Wistar rats. Results: The anti-inflammatory activity of traditional drug at 100mg/kg dose level showed significant (p<0.01, p<0.001) anti-inflammatory activity from 60 minutes onwards and it was maintained up to 240 minutes. The results were comparable with that of standard drug indomethacin 10 mg/kg.The antiseptic activity of traditional drug showed a better healing pattern with complete wound closure with significant change (p< 0.05) in % wound contraction was observed in standard and treated group within 12 and 15 days respectively while it was about 21 days in control rats. Conclusion: The results indicate that the traditional drugThippilirasayanam has a distinct approach to care neonate and children suffering from tonsillitis. It act as a preventive medicine that keep children healthy.