EVALUATION OF EFFECTS OF 1.2% ATORVASTATIN AS A LOCAL DRUG DELIVERY: A RANDOMIZED CONTROLLED CLINICAL STUDY

Aim: The aim of this randomized controlled clinical trial was to assess the clinical and radiographic effects of 1.2% Atorvastatin (ATV) gel as an adjunct to scaling and root planing in treating chronic periodontitis patients with and without Type II diabetes.

Materials and Methods: 40 subjects ageing between 30 to 50 years were included in the study and were divided into two groups: Group A (chronic periodontitis) and Group B (Type II diabetics with chronic periodontitis). Periodontal status was assessed by using plaque index, modified sulcular bleeding index(mSBI), probing pocket depth and clinical attachment level(CAL) at baseline and 6 months. Intrabony defect depth fill was assessed by comparing periapical radiographs taken at baseline and at 6 months.

Results: Both the groups showed significant improvements in all the parameters from baseline to 6 months with no significant difference during the intergroup comparison. However, in Group A, there was greater fill in mean intrabony defect compared to Group B with statistical significance during intra and intergroup comparison

Conclusion: Local delivery of 1.2% ATV showed beneficial effects on periodontium with improvement in all clinical parameters. Within the limits of this study, it can be concluded that ATV, can be used for periodontal regeneration in angular defects due to chronic periodontitis.