HEPATOPROTECTIVE ACTIVITY OF HOMALOMENA AROMATICA AGAINST CCL4 INDUCED LIVER INJURY IN SWISS ALBINO MICE

The in vivo hepatoprotective activity of Homalomena aromatica was evaluated in carbon tetrachloride-induced hepatic injury model in Swiss albino mice. Effects of the methanolic rhizome extracts of Homalomena aromatica (HAME) at a dose of 200 mg/kg body weight and 500 mg/kg body weight was tested for its efficacy on CCl4 (1ml/kg body weight) induced liver injury. Hepatic toxicity enzyme markers and histological parameters were studied. Daily oral administration of HAME (500 mg/kg) reduced liver toxicity marker enzyme activity significantly as compared to the control. The results were also supported by the histopathological studies. Recovery of the liver tissue was observed in the highest dose (500 mg/kg) of HAME. The progression of liver damage could be inhibited by the protective effect of HAME and the normal architecture of the liver could be preserved. The plant can therefore be a potential therapeutic candidate to treat liver injury.