CORRELATION OF SERUM OSTEOCALCIN LEVEL WITH THE INDICES OF OBESITY AND LIPID PROFILE IN TYPE II DIABETIC SUDANESE PATIENTS
Ogail Yousif Dawod
, Monami Mukherjee Mondal
, Amar Babikir Elhussein
, Asim Alaaeldin Osman
, Mohamed Abd Elrahim Ahmed
and Ali Mohamed Abdelrazig
- Department of Physical Therapy, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
- Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
- Department of Biochemistry, Nile College for Medicine and Medical Science, Khartoum, Sudan.
- Department of Physiology, Faculty of Medicine and Health Sciences, University of Gadarif, Sudan.
- Department of Physiology Faculty of Medicine, AlzaiemAlazhari University, Sudan.
- Department of Diagnostic Radiology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
- Abstract
- Keywords
- Cite This Article as
- Corresponding Author
Objectives:Osteocalcin, an osteoblast-specific protein, has recently been reported to affect energy metabolism, this study aimed to assess the relationship between serum total osteocalcin and measurements of adiposity and lipid profile in type II diabetic Sudanese patients.
Methods: In this cross-sectional study, 115 people with type II diabetes (34 men, 81 women) aged 18 to 94 years were enrolled in the study. Total osteocalcin and insulin were measured using ELISA (enzyme-linked immunosorbent assay) technique. Fasting blood glucose and lipid profile were measured by a spectrophotometer.
Results: Mean serum osteocalcin concentration in diabetic patients was significantly lower than those in control subjects (p ≤ 0.001). When the test was done between TOC and lipid profile, there was a moderate negative correlation between TOC and TCHOL. Which was statistically significant (P = 0.003). There was a moderate negative correlation between TOC and TG. Which was statistically non-significant (P = 0.057). There was a strong positive correlation between TOC and HDL. Which was statistically significant (P = 0.000). There was a weak positive correlation between TOC and LDL. That is statistically non-significant P = 0.105.
Conclusion:Our findings showed a statistically highly significant negative correlation between TOC and fasting blood glucose concentration. Similarly, the correlation between FBG and ucOC, age, BMI, TCHOL, and HDL showed a negative correlation that was not significant.
[Ogail Yousif Dawod, Monami Mukherjee Mondal, Amar Babikir Elhussein, Asim Alaaeldin Osman, Mohamed Abd Elrahim Ahmed and Ali Mohamed Abdelrazig (2023); CORRELATION OF SERUM OSTEOCALCIN LEVEL WITH THE INDICES OF OBESITY AND LIPID PROFILE IN TYPE II DIABETIC SUDANESE PATIENTS Int. J. of Adv. Res. 11 (Apr). 165-174] (ISSN 2320-5407). www.journalijar.com
Department of Physical Therapy, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Saudi Arabia
