INHIBITORY PROPERTY OF CHITOSAN EXTRACT FROM SHRIMP AGAINST BACTERIA ISOLATED FROM DIABETIC FOOT ULCER

Treatment of Diabetic Foot Ulcers (DFUs) is considerably challenging. Impaired wound healing may be caused by poor vascularization and dysfunction of the extracellular matrix, which leads to poor re epithelialization and increased risk of infection. In this study, we evaluated the inhibitory potential of shrimpderived chitosan against bacteriaisolatedfrom DFUwounds.Vannamei shrimp (Litopenaeusvannamei) presents potential as a raw material of micro chitosan production, because its shell contains chitin and chitosan. Chitosan is a natural polysaccharide with specific properties, including non-toxicity, biodegradability, and biocompatibility. It is obtained from the process of chitin deacetylation and has a free amino group (NH2) that makes this polycationic polymer a suitable antibacterial agent. The aim of this study was to extract chitosan from shrimp and to evaluate its antibacterial properties against organisms isolated from diabetic foot ulcer wounds. Shrimpwas collected and chitosan extraction was extracted. Isolation of bacteria was done from swabs of diabetic ulcer wounds. Analysis of antibacterial activity of shrimp-derived chitosan was done by well diffusion method. It was found that has potent antimicrobial properties against pathogens associated with diabetic ulcers. DFUs are a serious complication of diabetes that can lead to amputation if not treated properly. In addition to its antibacterial properties, chitosan is also non-toxic, biodegradable, and biocompatible. This makes it a promising candidate for use in wound dressings and other medical applications. Overall, the study showed that chitosan obtained from vannamei shrimp has the potential to be developed into a new and effective treatment for DFUs.