A Study on Nephroprotective and Antiurolithiasis activities of Ethanolic Extract of Asarum europaeum Leaves against Gentamicin Induced Nephrotoxicity in Wistar Rats

The drugs like gentamicin can show nephrotoxicity in the animals, after their administration. The normal functions of the cells are disturbed or completely lost due to the action of the drugs. Nephrolithiasis refers to calculi in the kidneys, which induces renal injury through intratubular obstruction and promote cell swelling and finally leads to chronic renal failure and papillary necrosis. The incidence of nephrolithiasis (kidney) and Ureterolithiasis (Ureter) is of significant importance in research, worldwide. The medicinal properties of plants have been investigated during recent years, due to their potent pharmacological activities, economic viability and low toxicity. Asarum europaeum is a traditional plant of India and used as anti-inflammatory, antioxidant, antitumorigenic, antiulcerogenic, hepatoprotective, antipyretic, diuretic and nephroprotective agent. The current study focused on the nephroprotective and antiurolithiatic activities of Asarum europaeum.