A MASTER REGULATORY GENE FOR EXTENDING HUMAN LIFESPAN THROUGH METABOLIC OPTIMIZATION, IMMUNOLOGICAL REJUVENATION, AND AI-GUIDED PRECISION MEDICINE

This paper explores the hypothetical gene AGEX-13, proposed as a master regulator capable of extending human lifespan to approximately 195 years by modulating metabolism, immunity, and other aging-related processes. Integrating insights from genomics, bioinformatics, gene therapy, immunology, and artificial intelligence, we outline AGEX-13s potential mechanisms, including enhanced mitochondrial function, optimized nutrient sensing, immunological rejuvenation, and improved genomic stability. We propose a multidisciplinary framework involving CRISPR-based gene editing, CAR-T cell therapies, and AI-driven longevity monitoring to achieve a disease-free, extended healthspan. While AGEX-13 remains theoretical, this study provides a comprehensive blueprint for its identification, functional validation, and therapeutic application, addressing both scientific feasibility and ethical considerations.