SURVIVAL AND PULMONARY TOXICITY IN NON-SMALL CELL LUNG CANCER :THE ROLE OF PRE-TREATMENT GTV VOLUME AND DOSIMETRIC PARAMETERS

Objective: To evaluate the impact of gross tumor volume (GTV) on overall survival (OS) and acute pulmonary toxicity in patients with non-small cell lung cancer (NSCLC) treated with three-dimensional conformal radiotherapy (3D-CRT).

Methods: We retrospectively analyzed clinical and dosimetric data from 65 patients treated at the Radiation Oncology Department of Hassan II University Hospital, Fez, between January 2012 and July 2022. Survival outcomes were assessed using Kaplan-Meier method. Survival according to GTV volume was analyzed using the Log-rank test, while associations between acute pulmonary toxicity and variables such as age >65 years, GTV volume, MLD, V20Gy, and V30Gy were assessed using the Chi-squared test, with statistical significance set at p 0.05

Conclusion: Smaller GTV volumes were associated with improved survival. Dosimetric parameters were predictive of pulmonary toxicity, highlighting the importance of individualized treatment planning.