REVIEW ON PRAKRITI-BASED PERSONALIZED MEDICINE: INTEGRATING AYURVEDA AND GENOMICS

The personalized medicine is transforming the present day clinical practice, by customizing the interventions based on individual biological differences.Tailor-made health systems based on personalized approach and Prakriti have been suggested in the ancient Indian system of medicine, Ayurveda where Prakriti is an individuals body constitution which comprises three doshas Vata, Pita and Kapha in relative proportions of these. Modern genomics and molecular biology, in recent years have supplied scientific bases to this age-old concept, and have entified associations between Prakriti types and genetic make-up, metabolic activity of the individual as well as immunological profile and disease predisposition. In this article, we critically examine the inclusion of Prakriti-based classification as crossways into genomic science and its implications in predictive, preventive, and personalized medicine. We also address recent findings on genome wide associations, transcriptomics, epigenetics and pharmacogenomics validating Prakriti as a biologically representative endophenotype. The integration of Ayurveda and modern omics technologies seems a successful journey towards future precision medicine.