PRIMARY HYPERHIDROSIS ACROSS ADOLESCENCE AND MIDDLE ADULTHOOD: AN EVIDENCE-BASED INTEGRATIVE REVIEW OF EPIDEMIOLOGY, PATHOPHYSIOLOGY, DIAGNOSIS, CONTEMPORARY MANAGEMENT, CONSTITUTIONAL HOMOEOPATHIC THERAPEUTICS, AND COMPARATIVE MATERIA MEDICA DIFFERENTIATION

Background: Primary hyperhidrosis is a chronic disorder characterized by excessive eccrine sweat production beyond physiological requirements for thermoregulation. The condition commonly begins during adolescence or early adulthood and substantially affects emotional well being, occupational performance, interpersonal relationships, and overall quality of life. Although traditionally regarded as a benign dermatological condition, increasing evidence suggests that primary hyperhidrosis is a complex neurocutaneous disorder involving autonomic nervous system dysregulation, sympathetic overactivity, genetic predisposition, and altered central thermoregulatory mechanisms. Contemporary management includes topical agents, systemic pharmacotherapy, iontophoresis, botulinum toxin injections, microwave thermolysis, and endoscopic thoracic sympathectomy. Constitutional homoeopathy proposes an individualized therapeutic approach based upon constitutional susceptibility and holistic patient assessment.