COMPUTATIONAL STUDY ON PROTEIN INTERACTIONS OF CDKN2C AND ITS IMPACT ON CANCER STUDIES

CDKN2C is a tumour suppressor that suppress bone cancers like osteosarcoma and multiple myeloma by regulating cell cycle. Deletions or mutations in the gene can leads to tumour progression and worst survival however over expression leads to radiation sensitivity, G1 phase arrest and trigger apoptosis in osteosarcoma. Study on CDKN2C protein and its role in bone cancer is right now gaining evidence and few of the proteins like CDKN1C, CDKN2D, CCNL2 show primary level interactions and gene CDK4 is found be co expressed with CCND1 through prediction analysis and observed co-expression of homologs in other species through STRING database tool.