Correlation between estradiol deficiency and clotting mechanism in postmenopausal women

Aging in women is associated by a major loss in ovarian hormone function and consequently of menopause around the age of 50 years old. The present study was conducted essentially to evaluate the concentrations of some clotting factors and biochemical parameters in postmenopausal women.A total number of women was 125, of those, 100 women were post menopause and subdivided into four subgroups according to their ages: First group (51-55 years), Second group (56-60 years), Third group (61-65 years), and Fourth group (66-70 years). Twenty five (25) subjects were premenopausal women, their ages ranged between 20-30 years old and served as a control group.Results of estradiol hormone (E2) were significantly lowering (p<0.05) in all groups of postmenopausal women in a comparison with premenopausal women. Values of Prothrombin time (PT) recorded a significant heightening (p<0.05) in first and fourth groups, and these values tend to be non-significantly different (p>0.05) in the remaining tested groups when compared with control group. Regarding the results of the activated partial thromboplastin time (APPT) were insignificantly different (p>0.05) in most postmenopausal women compared to control group.About concentrations of clotting factors, it have been found a progressive elevation (p<0.05) in concentration of fibrinogen (FI) of aging women as compared to the control group and its concentration recorded a negative correlation (r = 0.645) with estradiol hormone level in all the tested group. On the other hand, the concentrations of stable factor (F VII) and anti-hemophilic factor (F VIII) were significantly dropped (p<0.05) in all tested group of postmenopausal women and their concentration indicated a positive correlation (r = 0.423, r = 0.344 respectively) with levels of estradiol hormone in all tested groups. We can be suggested that a deficiency of estradiol hormone is associated with disturbances of hemostatic mechanism of postmenopausal women.