Phytochemical composition and in-vitro Anti-diabetic potential of Swietenia mahagoni seed pod.

Swietenia mahagoni seed pod was screened for its anti-hyperglycemic potential by using In-vitro assays. Dried powder of seed pod was used in glucose adsorption and glucose diffusion retardation index assay, where as the aqueous and methanol extract of the seed were used to study the inhibition of enteric enzymes (?-amylase and sucrase). The bark powder showed dose dependent glucose adsorption and glucose diffusion retardation index. Aqueous extract was more potent in inhibiting the activity of ?-amylase than methanol extract. There was no notable activity observed in case of sucrase assay. Overall, assays partly indicate the anti-hyperglycemic potency of the seed pod which may be mediated through the inhibition of enteric enzymes. Further investigations are needed to validate this observation