INVESTIGATIONS ON SOME CHEMICAL INDICES IN BLOOD OF DOGS AFTER EXPERIMENTAL ACUTE INTOXICATION WITH THE CARBAMATE INSECTICIDE CARBOFURAN.

Experiments for monitoring of changes in blood levels of some chemical indices were carried out in dogs after acute intoxication with the carbamate insecticide carbofuran (Carbosan 35 ??). The studies involved one control and 6 experimental groups of dogs (totaln=42),treated once orally with increasing doses of the preparation via oesophageal probe : 0.525 mg/kg (experimental group I), 1.05 mg/kg (experimental group II), 2.1 mg/kg (experimental group III), 3.5 mg/kg (experimental group IV), 5.25 mg/kg (experimental group V) and 10.5 mg/kg (LD50), (experimental group VI), corresponding to 1/20, 1/10, 1/5, 1/3, 1/2 and LD50, oral doses for albino rats. Blood samples were obtained from v. antebrachicephalicaorv. Jugularis in the course of 3 consecutive days prior to the treatment (hours -48, -24 and 0) and on post treatment hours 1, 3, 5, 7, 24 and 48 from all groups for analysis of calcium (Ca), inorganic phosphorus (P), magnesium (Mg), total (TBil) and direct bilirubin (DBil), urea (BUN), creatinine (Creat), triglycerides (TG), cholesterol? (Chole), plasma total protein (TP), albumin (Alb), blood glucose (Glu), potassium (K),chlorides (Cl) and sodium (Na). It was established that the tested carbamate insecticide caused increased the levels of TP, Glu, BUN, TG and Chole, and decrease Mg and K. There were no considerable changes in the levels of Creat, Alb, Tbil, Dbil, Ca, P, Cl and Na (??0.05).