SERUM ADROPIN AND ADIPOSE FATTY-ACID BINDING PROTEIN AT 6TH WEEK OF PREGNANCY ARE SIGNIFICANT PREDICTORS FOR DEVELOPMENT OF INSULIN RESISTANCE AT THE 24TH WEEK.

  • Departments of Obstetrics & Gynecology, Faculty of Medicine, Benha University.
  • Fellow & Researcher of Medical Biochemistry, Hospital Lab, Clinical Pathology department, Faculty of Medicine, Benha University.
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Objectives: To estimate serum Adropin (ADR) and Adipose fatty-acid-binding proteins (AFABP) levels at 6th wk and its relations with insulin resistance (IR) judged by homeostasis model assessment of IR (HOMA-IR) score and their predictive value for later development of gestational diabetes mellitus (GDM). Patients & Methods: 335 pregnant women gave blood samples for estimation of fasting blood glucose (FBG), and fasting serum insulin, ADR and AFABP. All women underwent the 75-Oral glucose tolerance test (OGTT) and HOMA-IR scoring at 6th and 24th week GA. Results: At 6th wk GA, 77 women had IR score >2 and 24th wk 39 women developed GDM and 106 had IR >2. Mean 6th wk serum ADR levels were significantly lower, while serum AFABP levels were significantly higher in GDM than non-GDM women. Statistical analyses defined 6th wk GA high serum AFABP and insulin, BMI and 2-hr PPBG, and low serum ADR, as significant predictors for development of IR at the 24th wk GA. Conclusion: Pregnancy induces maternal IR that was related to maternal BMI and may progress to GDM that was reported by a frequency of 11.9%. Development of GDM and IR were closely related to high serum AFABP and low serum ADR levels

  1. Vejrazkova D,?Vcelak J,?Vankova M,?Lukasova P,?Bradnova O,?Halkova T,?Kancheva R,?Bendlova B: Steroids and?insulin resistance?in?pregnancy. J Steroid Biochem Mol Biol.?2014; 139:122-9.
  2. Vejrazkova D, Vankova M, Lukasova P, Vcelak J, Cirmanova V, Haluzik M, Bendlova B: Specific metabolic characteristics of women with former gestational diabetes: the importance of adipose tissue. Physiol Res. 2017; 66(Suppl. 3):S349-S356.
  3. Mierzwicka A, Bolanowski M: New peptides players in metabolic disorders. Postepy Hig Med Dosw (Online). 2016; 70(0):881-6.
  4. Bao W, Baecker A, Song Y, Kiely M, Liu S, Zhang C: Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review. 2015; 64(6):756-64.
  5. Zhang Y, Lu JH, Zheng SY, Yan JH, Chen L, Liu X, Wu WZ, Wang F: Serum levels of nesfatin-1 are increased in gestational diabetes mellitus. Gynecol Endocrinol. 2017; 33(8):621-4.
  6. Furuhashi M, Hotamisligil GS: Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat. Rev. Drug Discov., 2008; 7: 489?503.
  7. Graupera I, Coll M, Pose E, Elia C, Piano S, Sol? E, Blaya D, Huelin P, Sol? C, Moreira R, de Prada G1, Fabrellas N, Juanola A1, Morales-Ruiz M2,3,5, Sancho-Bru P2,3, Villanueva C, Gin?s P: Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes. Sci Rep. 2017; 7(1):1829.
  8. Storch J, Thumser AE: Tissue-specific functions in the fatty acid-binding protein family. J. Biol. Chem., 2010; 285: 32679?83.
  9. Hotamisligil GS, Bernlohr DA: Metabolic functions of FABPs?mechanisms and therapeutic implications. Nat. Rev., 2015; 11: 592?605.
  10. Furuhashi, M., Furuhashi, M., Saitoh, S., Shimamoto, K. & Miura, T. Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases. Clin. Med. Insights Cardiol., 2015
  11. Huang CL, Wu YW, Hsieh AR, Hung YH, Chen WJ, Yang WS: Serum adipocyte fatty acid-binding protein levels in patients with critical illness are associated with insulin resistance and predict mortality. Crit. Care, 2013; 17(1): R22.
  12. Yolbas S,?Kara M,?Yilmaz M,?Aydin S,?Koca SS: Serum adropin level and ENHO gene expression in systemic sclerosis. Clin Rheumatol.?2016; 35(6):1535-40.
  13. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, et al.: Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metabolism, 2008; 8(6):468e481.
  14. Ghoshal S,?Stevens JR,?Billon C,?Girardet C,?Sitaula S,?Leon AS,?Rao DC,?Skinner JS,?Rankinen T,?Bouchard C,?Nu?ez MV,?Stanhope KL,?Howatt DA,?Daugherty A,?Zhang J,?Schuelke M,?Weiss EP,?Coffey AR,?Bennett BJ,?Sethupathy P,?Burris TP,?Havel PJ,?Butler AA: Adropin: An endocrine link between the biological clock and cholesterol homeostasis. Mol Metab.?2017 Dec 30. pii: S2212-8778(17)30758-5.
  15. Tuna BG, Atalay PB, Altunbek M, Kalkan BM, Dogan S: Effects of Chronic and Intermittent Calorie Restriction on Adropin Levels in Breast Cancer. Nutr Cancer. 2017; 69(7):1003-1010.
  16. Yosaee S,?Soltani S,?Sekhavati E,?Jazayeri S: Adropin- A Novel Biomarker of Heart Disease: A Systematic Review Article.
  17. Bray GA: Pathophysiology of obesity. Am J Clin Nutr, 1992; 55: 488S-94S.
  18. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series 854. Geneva: World Health Organization, 1995.
  19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia.1985; 28:412?19.
  20. International association of diabetes and pregnancy study groups (IADPSG) recommendations on the diagnosis and classification of hyperglycemia in pregnancy.?Diabetes Care.?2010; 33:676?682.
  21. Tinder P: Determination of blood glucose. Ann. Clin. Biochem.; 6:24, 1969.
  22. Makin HLJ, Gower DB: Analysis of vitamin D. Their Metabolites and Analogues, In: Steroid analysis. Springer, London, 2010; chapter 11, 967-1096.
  23. Topuz M,?Celik A,?Aslantas T,?Demir AK,?Aydin S,?Aydin S: Plasma adropin levels predict endothelial dysfunction like flow-mediated dilatation in patients with type 2 diabetes mellitus. J Investig Med.?2013; 61(8):1161-4.
  24. Syamsunarno MRAA, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N (2013) A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting. PLoS ONE 8(11): e79386.
  25. Shapiro GD,?Arbuckle TE,?Ashley-Martin J,?Fraser WD,?Fisher M,?Bouchard MF,?Monnier P,?Morisset AS,?Ettinger AS,?Dodds L: Associations between maternal triclosan concentrations in early?pregnancy?and gestational diabetes mellitus, impaired glucose tolerance, gestational weight gain and fetal markers of?metabolic function. Environ Res.?2018;161: 554-61.
  26. Mechanick JI,?Zhao S,?Garvey WT: Leptin, An Adipokine With Central Importance in the?Global?Obesity?Problem. Glob Heart.?2017 Dec 13. pii: S2211-8160(17)30119-9.
  27. Palatnik A,?Swanson K,?Churchill T,?Bilski A,?Grobman WA,?Miller ES: Association Between Type of Screening for Gestational Diabetes Mellitus and Cesarean Delivery.
  28. Kugishima Y,?Yasuhi I,?Yamashita H,?Sugimi S,?Umezaki Y,?Suga S,?Fukuda M,?Kusuda N: Risk factors associated with the development of postpartum diabetes in Japanese women with gestational diabetes. BMC Pregnancy Childbirth.?2018 Jan 8;18(1):19
  29. Cheung NW,?Jiang S,?Athayde N: Impact of the IADPSG criteria for gestational diabetes, and of obesity, on pregnancy outcomes. Aust N Z J Obstet Gynaecol.?2018 Jan 23. doi: 10.1111/ajo.12772. [Epub ahead of print]
  30. Ma HH, Yang SY, Wang P, Zhang JF: Evaluation of the value of plasma concentration of copeptin in the first prenatal visit to diagnose gestational diabetes mellitus. Acta Diabetol. 2017; 54(12):1123-9.
  31. Karcaaltincaba D,?Calis P,?Ocal N,?Ozek A,?Altug Inan M,?Bayram M: Prevalence of gestational diabetes mellitus evaluated by universal screening with a 75-g, 2-hour oral glucose tolerance test and IADPSG criteria. Int J Gynaecol Obstet.?2017; 138(2):148-151.
  32. Arbib N,?Gabbay-Benziv R,?Aviram A,?Sneh-Arbib O,?Wiznitzer A,?Hod M,?Chen R,?Hadar E: Third trimester abnormal oral glucose tolerance test and adverse perinatal outcome. J Matern Fetal Neonatal Med.?2017; 30(8):917-21.
  33. Huhn EA,?Massaro N,?Streckeisen S,?Manegold-Brauer G,?Schoetzau A,?Schulzke SM,?Winzeler B,?Hoesli I,?Lapaire O: Fourfold increase in prevalence of gestational diabetes mellitus after adoption of the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. J Perinat Med.?2017; 45(3):359-366
  34. Brown FM,?Wyckoff J: Application of One-Step IADPSG Versus Two-Step Diagnostic Criteria for Gestational Diabetes in the Real World: Impact on Health Services, Clinical Care, and Outcomes. Curr Diab Rep.?2017; 17(10):85.
  35. Shepherd E,?Gomersall JC,?Tieu J,?Han S,?Crowther CA,?Middleton P: Combined diet and exercise interventions for preventing gestational diabetes mellitus. Cochrane Database Syst Rev.?2017; 11:CD010443.
  36. Pan SC, Huang CC, Lin SJ, Chen BY, Chang CC, Leon Guo YL: Gestational diabetes mellitus was related to ambient air pollutant nitric oxide during early gestation. Environ Res. 2017; 158:318-23.
  37. Li JY,?Wu GM,?Hou Z,?Cao YM: Expression of C1q/TNF-related protein-3 (CTRP3) in serum of patients with gestational diabetes mellitus and its relationship with insulin resistance. Eur Rev Med Pharmacol Sci.?2017; 21(24):5702-5710.
  38. Lindsay KL, Brennan L, Kennelly MA, Curran S, Coffey M, Smith TP, Foley ME, Hatunic M, McAuliffe FM: Maternal metabolic response to dietary treatment for impaired glucose tolerance and gestational diabetes mellitus. Ir J Med Sci. 2018 Jan 20. doi: 10.1007/s11845-018-1744-y
  39. Fasshauer M, Bl?her M, Stumvoll M: Adipokines in gestational diabetes. Lancet Diabetes Endocrinol. 2014; 2(6):488-99.
  40. Zhang Y, Zhang HH, Lu JH, Zheng SY, Long T, Li YT, Wu WZ, Wang F: Changes in serum adipocyte fatty acid-binding protein in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnancy. J Diabetes Investig. 2016; 7(5):797-804.
  41. Li L, Lee SJ, Kook SY, Ahn TG, Lee JY, Hwang JY: Serum from pregnant women with gestational diabetes mellitus increases the expression of FABP4 mRNA in primary subcutaneous human pre-adipocytes. Obstet Gynecol Sci. 2017; 60(3):274-282
  42. Garin-Shkolnik T, Rudich A, Hotamisligil GS, Rubinstein M: FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes. 2014; 63(3):900-11.
  43. Svensson H, Wetterling L, Bosaeus M, Od?n B, Od?n A, Jennische E, Ed?n S, Holm?ng A, L?nn M: Body fat mass and the proportion of very large adipocytes in pregnant women are associated with gestational insulin resistance. Int J Obes (Lond). 2016; 40(4):646-53.
  44. Aydin S, Kuloglu T, Aydin S: Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus. 2013 Sep;47:66-70.
  45. Celik E, Yilmaz E, Celik O, Ulas M, Turkcuoglu I, Karaer A, Simsek Y, Minareci Y, Aydin S: Maternal and fetal adropin levels in gestational diabetes mellitus. J Perinat Med. 2013; 41(4):375-80.
  46. Beigi A, Shirzad N, Nikpour F, Nasli Esfahani E, Emamgholipour S, Bandarian F: Association between serum adropin levels and gestational diabetes mellitus; a case-control study. Gynecol Endocrinol. 2015; 31(12):939-41.
  47. Dąbrowski FA Jarmużek P, Gondek A, Cudnoch-Jędrzejewska A, Bomba-Opoń D, Wielgoś M: First and third trimester serum concentrations of adropin and copeptin in gestational diabetes mellitus and normal pregnancy. Ginekol Pol. 2016; 87(9):629-634.
  48. Gao?S,?McMillan RP,?Zhu Q,?Lopaschuk GD,?Hulver MW,?Butler AA: Therapeutic effects of?adropin?on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance.
  49. Stevens JR, Kearney ML, St-Onge MP, Stanhope KL, Havel PJ, Kanaley JA, Thyfault JP, Weiss EP, Butler AA: Inverse association between carbohydrate consumption and plasma adropin concentrations in humans. Obesity (Silver Spring). 2016; 24(8):1731-40.
  50. Zhang H, Jiang L, Yang YJ, Ge RK, Zhou M, Hu H, Liu H, Cui J, Li LL, Dong YF, Cheng XS, Chen R, Li P: Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss. Sci Rep. 2017; 7(1):17717.
  51. Yosaee S, Khodadost M, Esteghamati A, Speakman JR, Shidfar F, Nazari MN, Bitarafan V, Djafarian K: Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects. Am J Mens Health. 2017;11(2):426-434.
  52. Hill DJ: Placental control of metabolic adaptations in the mother for an optimal pregnancy outcome. What goes wrong in gestational diabetes? Placenta. 2018 Jan 9. pii: S0143-4004(18)30004-3

Amr Sharafeldeen and Raafat R. Mohammed. (2018); SERUM ADROPIN AND ADIPOSE FATTY-ACID BINDING PROTEIN AT 6TH WEEK OF PREGNANCY ARE SIGNIFICANT PREDICTORS FOR DEVELOPMENT OF INSULIN RESISTANCE AT THE 24TH WEEK., Int. J. of Adv. Res., 6 (02), 800-809, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/6496

Amr Sharaf El-Deen
Departments of Obstetrics & Gynecology, Faculty of Medicine, Benha University.

DOI:

Article DOI: 10.21474/IJAR01/6496      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6496

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