IN VITRO ANTI-ULCER ACTIVITY OF DIFFERENT EXTRACTS OF CISSUS QUADRANGULARIS
Syed Ahad Hussain
, Goutham Kumar Srigadi
, Chamakuri Subba Rao
, Syed Ahmedulla Hussaini
, Arige Srikanth
, Jashwanth Reddy Vootkuri
, Karnatham Anuja
, Pittala Rajasri
and Dasari Sneha
- Department of Pharmacy,Vaageswari College of Pharmacy, Karimnagar-505001.
- Abstract
- Keywords
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- Corresponding Author
Aim:The aim of this study was undertaken to assessin vitro H+-K+ ATPase inhibitory activity of different extracts of Cissus quadrangularis Linn.
Materials and Methods: Phytochemical and Phyto-analytical studies like total phenolic compound and total flavonoid contents from extract were quantified and H+-K+ ATPase inhibition assay was performed in presence of different concentrations(10,20,50 and 100 μg/ml) of standard (omeprazole),chloroform and methanolic extract.
Results:The extract has shown dose dependent significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was compared to standard Omeprazole.
Conclusions: Hence, from this study we have concluded that methanolic extract of C.quadrangularis has more inhibitory effect than chloroform extract.
Syed Ahad Hussain, Goutham Kumar Srigadi, Chamakuri Subba Rao, Syed Ahmedulla Hussaini, Arige Srikanth, Jashwanth Reddy Vootkuri, Karnatham Anuja, Pittala Rajasri and Dasari Sneha (2021); IN VITRO ANTI-ULCER ACTIVITY OF DIFFERENT EXTRACTS OF CISSUS QUADRANGULARIS, Int. J. of Adv. Res., 9 (04), 21-25, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/12652
Jawaharlal Nehru Technological University Hyderabad
India
