13Apr 2021

IN VITRO ANTI-ULCER ACTIVITY OF DIFFERENT EXTRACTS OF CISSUS QUADRANGULARIS

  • Department of Pharmacy,Vaageswari College of Pharmacy, Karimnagar-505001.
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Aim:The aim of this study was undertaken to assessin vitro H+-K+ ATPase inhibitory activity of different extracts of Cissus quadrangularis Linn.

Materials and Methods: Phytochemical and Phyto-analytical studies like total phenolic compound and total flavonoid contents from extract were quantified and H+-K+ ATPase inhibition assay was performed in presence of different concentrations(10,20,50 and 100 μg/ml) of standard (omeprazole),chloroform and methanolic extract.

Results:The extract has shown dose dependent significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was compared to standard Omeprazole.

Conclusions: Hence, from this study we have concluded that methanolic extract of C.quadrangularis has more inhibitory effect than chloroform extract.


[Syed Ahad Hussain, Goutham Kumar Srigadi, Chamakuri Subba Rao, Syed Ahmedulla Hussaini, Arige Srikanth, Jashwanth Reddy Vootkuri, Karnatham Anuja, Pittala Rajasri and Dasari Sneha (2021); IN VITRO ANTI-ULCER ACTIVITY OF DIFFERENT EXTRACTS OF CISSUS QUADRANGULARIS Int. J. of Adv. Res. 9 (Apr). 21-25] (ISSN 2320-5407). www.journalijar.com


Syed Ahad Hussain
Jawaharlal Nehru Technological University Hyderabad
India