IN VITRO ANTI-ULCER ACTIVITY OF DIFFERENT EXTRACTS OF CISSUS QUADRANGULARIS
Syed Ahad Hussain
, Goutham Kumar Srigadi
, Chamakuri Subba Rao
, Syed Ahmedulla Hussaini
, Arige Srikanth
, Jashwanth Reddy Vootkuri
, Karnatham Anuja
, Pittala Rajasri
and Dasari Sneha
- Department of Pharmacy,Vaageswari College of Pharmacy, Karimnagar-505001.
- Abstract
- Keywords
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Aim:The aim of this study was undertaken to assessin vitro H+-K+ ATPase inhibitory activity of different extracts of Cissus quadrangularis Linn.
Materials and Methods: Phytochemical and Phyto-analytical studies like total phenolic compound and total flavonoid contents from extract were quantified and H+-K+ ATPase inhibition assay was performed in presence of different concentrations(10,20,50 and 100 μg/ml) of standard (omeprazole),chloroform and methanolic extract.
Results:The extract has shown dose dependent significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was compared to standard Omeprazole.
Conclusions: Hence, from this study we have concluded that methanolic extract of C.quadrangularis has more inhibitory effect than chloroform extract.
[Syed Ahad Hussain, Goutham Kumar Srigadi, Chamakuri Subba Rao, Syed Ahmedulla Hussaini, Arige Srikanth, Jashwanth Reddy Vootkuri, Karnatham Anuja, Pittala Rajasri and Dasari Sneha (2021); IN VITRO ANTI-ULCER ACTIVITY OF DIFFERENT EXTRACTS OF CISSUS QUADRANGULARIS Int. J. of Adv. Res. 9 (Apr). 21-25] (ISSN 2320-5407). www.journalijar.com
Jawaharlal Nehru Technological University Hyderabad
India
