ANTIOXIDANTS AND ANTI-INFLAMMATION POTENTIALOF AMARANTHUS VIRIDIS LINN AGAINST 3-NP-INDUCED HUNTINGTONS DISEASE IN RATS
- Department of Pharmacology, Sri Adichunchinagiri College of Pharmacy, B.G.Nagar-541418, Mandya Distict, Karnataka, India.
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Huntingtons disease (HD) is an autosomal dominant neurodegenerative disease. Accordingly, 3-nitropropionic acid (3-NP) has been found to effectively produce HD-like symptoms. Amaranthus viridis Linn (HAEAV), popularly known in Chauraiya in Hindi, may act as a neuroprotective agent in vitro andin vivo. We evaluated the hypothesis that the hydro-ethanolic extract of Amaranthus viridis Linn could prevent behavioral and oxidative alterations induced by 3-NP in rats. 30 albino Wistar female rats were divided into 5 groups: (1) control, (2) HAEAV(400Ã¢Â€Â‰mg/kg), (3) 3-NP, (4) HAEAV(200Ã¢Â€Â‰mg/kg) + 3-NP, and (5) HAEAV(400Ã¢Â€Â‰mg/kg) + 3-NP.Animals in groups 3, 4, and 5 received 15Ã¢Â€Â‰mg/kg 3-NP daily from days 8Ã¢Â€Â“14. At day 14, parameters of locomotor activity and biochemical evaluations were performed. Indeed, rats treated with 3-NP showed decreased locomotor activity compared to controls. Additionally, 3-NP increased levels of reactive oxygen species and lipid peroxidation and decreased ratio of CAT, TT, and GSHactivityinbrain tissues. Our results suggest that rats pretreated with HAEAVprior to 3-NP treatment showed neuroprotective effects when compared to 3-NP treated controls, which may be due to its antioxidant properties.
[Pooja RC (2022); ANTIOXIDANTS AND ANTI-INFLAMMATION POTENTIALOF AMARANTHUS VIRIDIS LINN AGAINST 3-NP-INDUCED HUNTINGTONS DISEASE IN RATS Int. J. of Adv. Res. 10 (Aug). 411-420] (ISSN 2320-5407). www.journalijar.com
Department of pharmacology, Sri Adichunchanagiri college of pharmacy, BG Nagara-571418.
Article DOI: 10.21474/IJAR01/15195
DOI URL: http://dx.doi.org/10.21474/IJAR01/15195
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