BRASSINOSTEROIDS A INTER KINGDOM SIGNALING MOLECULES MODULATING STERIOIDOGENESIS IN POLYCYSTIC OVARY SYNDROME AN IN SILICO STUDY

Understanding the influence of ubiquitously present plant hormone brassinosteroids on ovarian sterioidogenesis in polycystic ovarian syndrome(PCOS) is currently of interest.Ovarian tissue sterioidogenesis depends upon the availability of cholesterol besides thecatalytic activity of 17 dehydrogenases and aromataseis a major regulatory step in ovarian steroidogenicpathway.Ovarian testosterone and estradiol biosynthesis is feedback regulated by GnRH, FSH and LH acting through membrane bound hormone receptors. Brassinosteroids is a polyoxygenated derivative of cholesterol,showing structural similarities with animal oxysterol and available to human through diet,exhibitedantihyperglycemic, anticholesterolemic and antiviral effects. Presentstudy intends to investigatebrassinosteroids againstaromatase,17β hydroxysteroid dehydrogenase, androgen and estrogen receptors asa therapeutic target.ADMETproperties of brassinosteroids molecules were evaluated using swiss ADME tool.In Silico molecular docking study were performed via AutoDock version 4.0.Brassinosteroids molecules were exhibits high docking score against the aromatase,17 hydroxysteroid dehydrogenase,androgen and estrogen receptors as compared to standard ligand.Dietary intake of brassinosteroids can be potentially down regulatingovarian sterioidogenesis in PCOS.