HISTOPATHOLOGICAL TOXICITY EVALUATION OF DELTAMETHRIN ON THE INTEGRITY OF OVARIAN FOLLICLES ON MICE (Mus musculus L.)

Deltamethrin, a widely used pyrethroid insecticide,can induce oxidative stress through the production of reactive oxygen species (ROS), leading to cellular damage and affecting ovarian function. This study investigated the effects of deltamethrin exposure on the ovarian structure of female mice (Mus musculus L.). Fifteen mice were divided into three groups: a control group, and two treatment groups receiving deltamethrin at doses of 18 mg/kgBW and 36 mg/kgBW for 14 days. Ovarian follicle data were analyzed using one-way ANOVA followed by Duncan’s Multiple Range Test (DMRT). The results showed that deltamethrin exposure caused ovarian structural damage, characterized by a reduction in secondary and Graafian follicles and an increase in atretic follicles. These findings indicate that deltamethrin adversely affects ovarian health in mice.