Anti-Atherosclerosis Activity of Seed oil of Punica Granatum Linn in Triton X-100 induced hyperlipidemic rats.

The present study is designed to evaluate the effect of pomegranate seeds oil on lipid profiles in Triton X-100 induced hyperlipidemia in ratus norvegicus rats. The solution of triton-X 100 has successfully been used to induce hyperlipidemia in rats in triton X-100 induced hyperlipidemic model. Treatment with pomegranate seeds oil at a 750 mg/kg dose significantly reduced the serum TC, TG, & LDL-C levels & increased the serum HDL-C levels when compared to hyperlipidemic control. It is widely accepted that reduction in plasma HDL is a risk factor for developing atherosclerosis. Increased levels of HDL after administration of pomegranate seeds oil concluded that the extract is a potent cardio-protective agent & this effect due to super CLA i.e. Punicic acid present in pomegranate seeds oil. Pomegranate seeds oil contains about 70-75 % punicic acid.